So in a pure dead space scenario, which I assume is only hypothetical, what's happening to that desaturated Hb? Do we just assume that it disappears? Which is what happens in Pulm Embolism as you said. Because it doesn't reach the arterial side, it doesn't mix with the normally saturated Hb coming from the normal alveoli, and so doesn't affect the overall saturation of arterial blood or PaO2.īut then realistically all that blood has to go somewhere right? It should land up going to the normally ventilated alveoli and decrease the V/Q ratio there because its increasing Q, blood flow. Ryan explains it in his video is that pure dead space doesn't cause hypoxemia because the desaturated Hb thats going to the dead space alveoli never reaches the arterial side of the circulation, since there's a block in the vessel. Yeah, but why does dead space only affect CO2? Since Q goes up, V/Q goes down - that's V/Q mistmach which causes hypoxemia. Areas of lung that are perfused in PE have very high blood flow (Q) since blood cannot go through all normal channels due to clot. Hypoxemia occurs in PE due to V/Q mismatch. Also there is hypoxemia in PE, but not because of the dead space (because dead space doesn't case low O2). This is because patients hyperventilate to keep Co2 normal despite dead space. There is dead space, but usually not hypercapnia. Leaves more CO2 behind in the blood so CO2 rises. Air goes in and out without picking up CO2. Dead space is ventilated but not perfused. Net result: oxygen fails to improve O2.ĭead space: Has nothing to do with O2, only CO2. So oxygen does not help because it can't get to shunt areas (no ventilation) and it can get to non-shunt areas which are already fully oxygenated. Non-shunted areas are fully oxygenated (100%). In a shunt, blood good from right heart to left heart without passing ventilated areas (i.e., does not pick up oxygen).
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